Modified Silicone Elastomer Vaginal Gels for Sustained Release of Antiretroviral HIV Microbicides
نویسندگان
چکیده
منابع مشابه
Modified silicone elastomer vaginal gels for sustained release of antiretroviral HIV microbicides.
We previously reported nonaqueous silicone elastomer gels (SEGs) for sustained vaginal administration of the CCR5-targeted entry inhibitor maraviroc (MVC). Here, we describe chemically modified SEGs (h-SEGs) in which the hydrophobic cyclomethicone component was partially replaced with relatively hydrophilic silanol-terminated polydimethylsiloxanes (st-PDMS). MVC and emtricitabine (a nucleoside ...
متن کاملLong-term, controlled release of the HIV microbicide TMC120 from silicone elastomer vaginal rings.
OBJECTIVES The feasibility of providing prolonged and controlled release of the experimental non-nucleoside reverse transcriptase inhibitor TMC120 from a silicone vaginal ring in quantities sufficient to maintain a vaginal concentration offering protection against heterosexual HIV transmission was investigated. METHODS Core-type, silicone elastomer vaginal rings containing TMC120 were manufac...
متن کاملVaginal rings for delivery of HIV microbicides
Following the successful development of long-acting steroid-releasing vaginal ring devices for the treatment of menopausal symptoms and contraception, there is now considerable interest in applying similar devices to the controlled release of microbicides against HIV. In this review article, the vaginal ring concept is first considered within the wider context of the early advances in controlle...
متن کاملSustained release of proteins from a modified vaginal ring device.
A new vaginal ring technology, the insert vaginal ring (InVR), is presented. The InVR overcomes the current shortfall of conventional vaginal rings (VRs) that are generally ineffectual for the delivery of hydrophilic and/or macromolecular actives, including peptides, proteins and antibodies, due to their poor permeation characteristics in the hydrophobic polymeric elastomers from which VRs are ...
متن کاملFabrication of a Reservoir Ring for Sustained and Prolonged Release of Levonorgestrel for Vaginal Administration
Introduction: More than one-third of women experience abnormal uterine bleeding (AUB) during their lifetime. One of the treatment methods of this disease is hormone therapy. Vaginal rings (VRs) containing progesterone hormones could be a good choice for treatment. In this study, the design and construction of a reservoir ring with the ability to release levonorgestrel hormone has been investiga...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Sciences
سال: 2014
ISSN: 0022-3549
DOI: 10.1002/jps.23913